Genome-Wide Association Analysis of Lung Diseases

I am in Ft. Lauderdale today at the American Physiological Society (APS) conference on Physiological Genomics and Proteomics of Lung Disease. I was invited to speak about our work on "Exploiting Expert Knowledge for Genome-Wide Genetic Analysis". The technical details covered in the talk have been covered previously in this blog. These novel methods for detecting epistasis on a genome-wide scale will eventually be applied to our study of adult respiratory distress syndrome (ARDS) in patients with traumatic injury. The ascertainment and genetic analysis of ARDS following traumatic injury is funded by a five-year grant from the NIH (R01-HD047447, PI-Moore). We just finished the second year of the study and have successfully recruited over 1,000 subjects for the study. We have exceeded our three-year recruitment goal of n=750 after only two years.