Epistasis Blog

From the Computational Genetics Laboratory at Dartmouth Medical School (www.epistasis.org)

Saturday, March 08, 2008

New Epistasis Papers

Here are a few new papers that are worth looking at:

Hallgrimsdottir IB, Yuster DS. A complete classification of epistatic two-locus models.BMC Genet. 2008 Feb 19;9(1):17 [PubMed]

Mechanic LE, Luke BT, Goodman JE, Chanock SJ, Harris CC. Polymorphism Interaction Analysis (PIA): a method for investigating complex gene-gene interactions. BMC Bioinformatics. 2008 Mar 6;9(1):146 [PubMed]

Cooper TF, Remold SK, Lenski RE, Schneider D. Expression Profiles Reveal Parallel Evolution of Epistatic Interactions Involving the CRP Regulon in Escherichia coli. PLoS Genet. 2008 Feb 15;4(2):e35 [PubMed]

Monday, March 03, 2008

The Critical Need for Computational Intelligence in Human Genetics

My essay on "The Critical Need for Computational Intelligence in Human Genetics" has been published as a Hot Topics piece in Computing Reviews. You can find the essay here. The purpose of this essay is to communicate to computer scientists the computational challenges facing geneticists with the goal of inspiring some of them to help tackle these problems.