A Decade Later, Genetic Map Yields Few New Cures
This NYT article highlights the grand failure of GWAS. However, the writer fails to uncover the real reason this hasn't worked - complexity. As I point in a recent Nature Reviews Genetics viewpoint piece (see May 18, 2010 post below), this grand failure should not be a surprise to anyone that marvels at the complexity of genetic architecture. The NYT needs to interview the researchers in the field that are thinking deeply about the problem and not those that are just throwing more technology at the genome.
A Decade Later, Genetic Map Yields Few New Cures [NYT]
posted by Jason H. Moore, Ph.D. @ 7:12 AM
1 Comments:
Guaranteed we won't come close to finding the missing heritability for a trait --even with the addition of tons of rare SNPs -- if we don't comprehend that the effect sizes combine, amplify, distort, etc..., as the signals pass through biological circuits.
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