Epistasis Blog

From the Computational Genetics Laboratory at Dartmouth Medical School (www.epistasis.org)

Saturday, June 15, 2013

JAMIA Special Issue on Translational Bioinformatics

The June, 2013 issue of the Journal of the American Medical Informatics Association (JAMIA) contains papers published from the 2012 Translational Bioinformatics Conference (TBC). The list of papers can be found here.

We have the following two papers in the special issue. Both are open access.

Hu T, Chen Y, Kiralis JW, Collins RL, Wejse C, Sirugo G, Williams SM, Moore JH. An information-gain approach to detecting three-way epistatic interactions in genetic association studies. J Am Med Inform Assoc. 2013 Jul 1;20(4):630-6. [PubMed]

Urbanowicz RJ, Andrew AS, Karagas MR, Moore JH. Role of genetic heterogeneity and epistasis in bladder cancer susceptibility and outcome: a learning classifier system approach. J Am Med Inform Assoc. 2013 Jul 1;20(4):603-12. [PubMed]

This paper from Yves Lussier is also highly relevant to the complexity of the genotype-phenotype map.

Lee Y, Li H, Li J, Rebman E, Achour I, Regan KE, Gamazon ER, Chen JL, Yang XH, Cox NJ, Lussier YA. Network models of genome-wide association studies uncover the topological centrality of protein interactions in complex diseases. J Am Med Inform Assoc. 2013 Jul 1;20(4):619-29. [PubMed]

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